Menopause, Metabolism, and GLP-1 with Dr Fionnuala Barton

Menopause brings hormonal shifts that can affect metabolism and body composition, often leading to increased fat and changes in fat distribution, known as "menopause belly." The drop in hormones like oestrogen during this time can lead to more fat storage and less muscle mass, impacting overall metabolic health.

Hormonal Changes and Metabolism

During menopause, declining oestrogen levels can lead to increased fat storage and inflammation, affecting metabolism. This hormonal change also causes a shift in fat distribution, with more visceral fat accumulating around internal organs, which can further impact metabolic health negatively.

Blood Sugar and Insulin Sensitivity

Menopause can alter how the body handles blood sugar, often leading to higher blood sugar levels and increased insulin resistance. This can contribute to more visceral fat and ongoing metabolic issues, making it crucial to maintain insulin sensitivity during this phase.

The Role of GLP-1 Medications

GLP-1 medications, initially for type 2 diabetes, are now recognised for their benefits in managing menopause-related metabolic changes. They help improve insulin secretion, reduce appetite, and slow gastric emptying, aiding in weight loss and better blood sugar control. Combining GLP-1 with hormone replacement therapy (HRT) can enhance these benefits, offering a comprehensive approach to managing menopause symptoms.

Lifestyle Integration

For best results, GLP-1 medications should be paired with lifestyle changes like balanced nutrition, regular strength training, and good sleep. Building lean muscle through resistance training is key to countering muscle loss and boosting metabolism. A diet rich in protein, fibre, and healthy fats supports weight management and overall health.

Safety and Considerations

While generally safe, GLP-1 medications can cause side effects like nausea and changes in appetite. Starting with a low dose and gradually increasing can help manage these effects. It's also important to stay hydrated and maintain a balanced diet.

Access to these medications may depend on BMI, but ongoing research is exploring their broader benefits beyond weight loss, including reducing inflammation and improving metabolic health.

In summary, menopause can challenge metabolic health, but with the right mix of medical and lifestyle strategies, women can manage these changes effectively. GLP-1 medications, combined with HRT and lifestyle adjustments, offer promising solutions for navigating menopause-related metabolic shifts.